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Description of Individual Course Units| Course Unit Code | Course Unit Title | Type of Course Unit | Year of Study | Semester | Number of ECTS Credits | | OTİD529 | Molecular Endocrinology | Elective | 1 | 1 | 6 |
| | Level of Course Unit | | Third Cycle | | Objectives of the Course | | The main aim of the course is to have information about the general structures and properties of hormones, classification according to their chemical structures, functions, biosynthesis and degradation, molecular action mechanisms, hormone receptors and molecular signal transmission mechanisms that play a role in their activation. In addition, to understand the clinical importance of hypothalamus, pituitary hormones, pancreatic hormones, adrenal hormones, gonads and steroid hormones and gastrointestinal hormones in physiological and pathological processes and to enable students to have knowledge about hormone determination methods, to gain a command of the literature by using this information and to prepare lectures, seminars, and articles. To gain research planning and preparation skills. | | Name of Lecturer(s) | | Doç. Dr. Bülent BAYRAKTAR | | Learning Outcomes | | 1 | Will be able to explain the endocrine system and hormone definition, the classification of hormones, their functions and molecular mechanisms of action. | | 2 | Will be able to explain hormone biosynthesis, regulation and degradation, Hormone receptors and molecular signal transduction mechanisms involved in their activation. | | 3 | Will be able to explain the formation mechanisms of diseases related to hormonal disorders. | | 4 | Define hormone determination methods and list their functions. | | 5 | Will be able to explain the molecular signal transduction mechanisms that play a role in hormone receptors and their activation. |
| | Mode of Delivery | | Normal Education | | Prerequisites and co-requisities | | NOT | | Recommended Optional Programme Components | | NOT | | Course Contents | | Introduction to Molecular Endocrinology
General endocrinology (General Properties of Hormones: Production at Cellular Level, Transport to Target Cells, Mechanisms of Action in Target Cells and Feedback Mechanisms),
Classification of Hormones and Endocrine Glands
Mechanisms Controlling Hormone Release, Effect Mechanisms of Hormones
Hormone signaling: Hormone receptor, types and secondary messengers
Receptors, G-protein and its activity, Cell surface receptors, Nuclear receptors, Regulation of receptors, Ion channels and electrical activities. Cell connections. Cell connections, Endocrine pathways
Midterm
Gonadal Hormones and Endocrinology of Reproductive Processes in Mammals and Poultry
Molecular mechanisms of diseases related to hormone deficiency
Molecular mechanisms of diseases related to hormone deficiency
Comparative Endocrinology
Comparative Endocrinology
Principles of advanced molecular techniques used in the detection of endocrine deficiencies
Analysis methods of hormones
final exam | | Weekly Detailed Course Contents | |
| 1 | Introduction to Molecular Endocrinology | NOT | NOT | | 2 | General endocrinology (General Properties of Hormones: Production at Cellular Level, Transport to Target Cells, Mechanisms of Action in Target Cells and Feedback Mechanisms) | NOT | NOT | | 3 | Classification of Hormones and Endocrine Glands | NOT | NOT | | 4 | Mechanisms Controlling Hormone Release, Effect Mechanisms of Hormones | NOT | NOT | | 5 | Hormone signaling: Hormone receptor, types and secondary messengers | NOT | NOT | | 6 | Receptors, G-protein and its activity, Cell surface receptors, Nuclear receptors, Regulation of receptors, Ion channels and electrical activities. Cell connections. Cell connections, Endocrine pathways | NOT | NOT | | 7 | MİDTERM | NOT | NOT | | 8 | Gonadal Hormones and Endocrinology of Reproductive Processes in Mammals and Poultry | NOT | NOT | | 9 | Molecular mechanisms of diseases related to hormone deficiency | NOT | NOT | | 10 | Molecular mechanisms of diseases related to hormone deficiency | NOT | NOT | | 11 | Comparative Endocrinology | NOT | NOT | | 12 | Comparative Endocrinology | NOT | NOT | | 13 | Principles of advanced molecular techniques used in the detection of endocrine deficiencies | NOT | NOT | | 14 | Analysis methods of hormones | NOT | NOT | | 15 | Final Exam | NOT | NOT |
| | Recommended or Required Reading | | - Fizyoloji: Baki YILMAZ
- Fizyoloji Ders Kitabı. Vücut Isısı ve Sindirim: F. BÖLÜKBAŞI
- Pratik Fizyoloji: T. KONUK
- Fizyoloji Ders Kitabı: Ahmet NOYAN
- Tıbbi Fizyoloji: AC Guyton
- Harper s Illustrated Biochemistry. Murray RK, Bender DA, Botham KM, Kennelly PJ, Rodwell VW. McGrawHill Lange, 28 th edition, 2009.
- Newsholme, EA and Leech, TR. Functional Biochemistry in Health and Disease 2010, WILEY-BLACKWELL, Oxford.
- Textbook of Biochemistry with Clinical Correlations. Thomas M. Devlin. Seventh Edition 2011, John-Wiley& Sons Inc. Publication, USA. | | Planned Learning Activities and Teaching Methods | | | Assessment Methods and Criteria | |
| Midterm Examination | 1 | 100 | | SUM | 100 | |
| Final Examination | 1 | 100 | | SUM | 100 | | Term (or Year) Learning Activities | 30 | | End Of Term (or Year) Learning Activities | 70 | | SUM | 100 |
| | Language of Instruction | | | Work Placement(s) | | NOT |
| | Workload Calculation | |
| Midterm Examination | 1 | 3 | 3 | | Final Examination | 1 | 3 | 3 | | Attending Lectures | 14 | 1 | 14 | | Field Work | 10 | 10 | 100 | | Criticising Paper | 6 | 10 | 60 | |
| Contribution of Learning Outcomes to Programme Outcomes | | LO1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | | | 1 | 1 | | | LO2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | | | 1 | 1 | | | LO3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | | | 1 | 1 | | | LO4 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | | | 1 | 1 | | | LO5 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | | | 1 | 1 | |
| | * Contribution Level : 1 Very low 2 Low 3 Medium 4 High 5 Very High |
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