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Description of Individual Course Units| Course Unit Code | Course Unit Title | Type of Course Unit | Year of Study | Semester | Number of ECTS Credits | | KTY135 | Metalloproteins | Elective | 1 | 1 | 6 |
| | Level of Course Unit | | Second Cycle | | Objectives of the Course | | Educating the linkages of the organonons and their bases related to proteins, which is related to the teaching of these courses. At the end of these courses, the structure stability and reactivity properties of the organometallic protein will be designed, such as the production of metallo-elements and the chemistry of the university students. | | Name of Lecturer(s) | | Dr. Öğr. Üyesi Yahya Yasin YILMAZ | | Learning Outcomes | | 1 | Gaining the ability to suggest its potential function when given structural information about the coordination environment of a particular transition metal ion in a biological molecule | | 2 | To be able to find, read and explain the content of scientific articles in this field | | 3 | To be able to describe the structure and functions of enzymes and proteins containing metal cofactors. |
| | Mode of Delivery | | Normal Education | | Prerequisites and co-requisities | | | Recommended Optional Programme Components | | | Course Contents | | Relationship of sodium and potassium with proteins, structure and function of sodium and potassium channel proteins in membranes, Magnesium-activated enzyme, calcium and its related enzymes, Are there proteins and vanadium in enzymes, Chromium-containing proteins?, Manganese-containing enzymes and proteins, Iron and related proteins in heme , iron sulfur proteins coordinated with oxygen and nitrogen, structure and function of non-heme iron proteins, iron storage and transport, oxygen and nitrogen coordinated, structure and function of non-heme iron proteins, iron storage and transport, cobalt and its related proteins in vitamin B12, nickel-containing enzymes, reduction of inorganic molecules, activation and transport of dioxygen, copper proteins, multi-copper oxidases, copper in electron transfer proteins, proteins with different functions containing copper, Metalloenzymes and zinc centers in related proteins, zinc finger proteins, other zinc proteins, metallothioneins and Emerging topics and models on insulin, Molybdenum or tunsten containing proteins and enzymes, Metalloproteins | | Weekly Detailed Course Contents | |
| 1 | Relationship of sodium and potassium with proteins, structure and function of sodium and potassium channel proteins in membranes | | | | 2 | Magnesium-activated enzyme, calcium and its related enzymes | | | | 3 | Vanadium in proteins and enzymes, Are there proteins containing chromium?, Enzymes and proteins containing manganese | | | | 4 | Iron and related proteins in heme, iron sulfur proteins coordinate with oxygen and nitrogen, structure and function of non-heme iron proteins, iron storage and transport | | | | 5 | Structure and function of non-heme iron proteins coordinated with oxygen and nitrogen, iron storage and transport | | | | 6 | Cobalt and related proteins in vitamin B12, Nickel-containing enzymes | | | | 7 | Copper proteins in reduction of inorganic molecules, activation and transport of dioxygen, multi-copper oxidases, copper in electron transfer proteins, copper-containing proteins with different functions | | | | 8 | Midterm exam | | | | 9 | Zinc centers in metalloenzymes and related proteins, zinc finger proteins, other zinc proteins, metallothionines and insulin | | | | 10 | Proteins and enzymes containing molybdenum and tungsten | | | | 11 | Emerging issues and models on Metallo Proteins | | | | 12 | Report Submission | | | | 13 | Report Submission | | | | 14 | Report Submission | | | | 15 | Final exam | | |
| | Recommended or Required Reading | | P. M. Harrison, R. J. Hoare, “Metals in Biochemistry”, Chapman ansd Hall,(1980) R.H.Holm, E.I.Soloman et al., “Bioinorganic Enzymology”, Chemical Reviewes,(1996) S. J. Lippard, J .M. Berg, “Bioinorganic Chemistry”, University Science Books, (1994) | | Planned Learning Activities and Teaching Methods | | | Assessment Methods and Criteria | |
| Midterm Examination | 1 | 15 | | Attending Lectures | 1 | 15 | | Discussion | 1 | 10 | | Report Preparation | 1 | 15 | | Report Presentation | 1 | 10 | | Criticising Paper | 1 | 15 | | Self Study | 1 | 10 | | Individual Study for Mid term Examination | 1 | 10 | | SUM | 100 | |
| Final Examination | 1 | 20 | | Report Preparation | 1 | 20 | | Report Presentation | 1 | 20 | | Writing Paper | 1 | 20 | | Individual Study for Final Examination | 1 | 20 | | SUM | 100 | | Term (or Year) Learning Activities | 40 | | End Of Term (or Year) Learning Activities | 60 | | SUM | 100 |
| | Language of Instruction | | | Work Placement(s) | |
| | Workload Calculation | |
| Midterm Examination | 1 | 1 | 1 | | Final Examination | 1 | 2 | 2 | | Discussion | 14 | 3 | 42 | | Report Preparation | 6 | 5 | 30 | | Report Presentation | 3 | 1 | 3 | | Writing Paper | 6 | 5 | 30 | | Criticising Paper | 14 | 3 | 42 | | Individual Study for Mid term Examination | 1 | 10 | 10 | | Individual Study for Final Examination | 1 | 15 | 15 | |
| Contribution of Learning Outcomes to Programme Outcomes | | LO1 | 3 | 4 | 5 | 3 | 4 | 3 | 5 | 5 | 5 | 4 | 5 | 3 | 5 | 3 | 4 | 5 | 5 | | LO2 | 5 | 4 | 3 | 4 | 3 | 5 | 3 | 5 | 4 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | | LO3 | 5 | 3 | 2 | 5 | 3 | 4 | 5 | 3 | 5 | 4 | 3 | 5 | 3 | 4 | 3 | 3 | 5 |
| | * Contribution Level : 1 Very low 2 Low 3 Medium 4 High 5 Very High |
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